Pharma: visit PTC Organics' poster at MPPCC on October 7th!

PTC Tip of the Month
Why Companies Miss PTC Opportunities

It is very likely that R&D departments and production plants just like yours are missing major opportunities to achieve very high performance and sometimes crucial performance using PTC. For example, time has just about run out on one current high profile cyanide/chloride exchange for a blockbuster pharmaceutical actually being considered for process change. Five major reasons for missing PTC opportunities are described in detail in an article by Halpern published in 1996 (click here) and unfortunately continues to be relevant today. Are you aware of any missed PTC opportunities?

The five reasons companies miss PTC opportunities are: [1] didnít think of PTC at the crucial decision stage, [2] didnít have the confidence that the PTC option can be developed within the deadline, [3] didnít obtain promising results within 3-10 experiments, [4] the process wasnít feasible (without applying highly specialized PTC expertise), [5] resistance to change. To overcome these reasons, see PTC Option Consultation below.

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PTC Training
2-Day PTC Course in Newark and Chicago

The course "Practical Phase-Transfer Catalysis" will be conducted in Newark, New Jersey on Feb 15-16, 2005 and in Chicago on April 12-13, 2005. "Practical Phase-Transfer Catalysis" can also be conducted at your company anytime (North America, Europe or Japan) as a private in-house course. More than 530 chemists, engineers and managers at nearly 100 companies have participated in this highly rated course from 1996 to 2004. Click here for details and agenda or contact us by E-mail or telephone (+1 856-222-1146) or fax (+1 856-222-1124).

New PTC Service
PTC Option Go/No-Go Consultation

Provide a quick and cost-effective key decision aid during initial project planning, whether to pursue evaluation of phase-transfer catalysis as an option to achieve success or breakthrough performance for an organic reaction/process, consisting of uniquely qualified expert opinion and supported by 28 years of PTC experience and documented evidence.

Benefit & When To Use
Can be crucial to achieve highly effective R&D for organic chemical reactions/processes during:

PTC Organics will deliver a written confidential "PTC Option Opinion" for a specific organic reaction which will include

Initiating the Project
To initiate project or obtain attractive pricing for 2005 budget planning, contact Marc Halpern at tel +1 856-222-1146, fax: +1 856-222-1124 or E-mail.

PTC Reaction of the Month
PTC/NaOH Alternative to Potassium t-Butylate

This patent describes a preferable 2-step addition reaction between adiponitrile and acrylonitrile using PTC/NaOH. A one-step process also compared using potassium t-butylate and Bu4NHSO4/NaOH (results of the one-step process were not impressive). This is yet another example that t-butylate can be replaced by PTC/NaOH because PTC really does enhance the basicity of hydroxide to a surprising degree! Schelhaas, M.; Jautelat, M.; (Bayer) US Patent 6,790,976, 14-Sep-2004

Phase-Transfer Catalyst of the Month
Imidazolium Ionic Liquids

Ionic liquids are being used as recoverable non-volatile reaction solvents which act as phase-transfer catalysts/agents since they are a form of N-quats. These materials are liquid at the reaction temperature, typically under 100oC. 
Very expensive relative to other phase-transfer catalysts...though must estimate cost-benefit on a performance basis, including environmental advantages. 

Availability, Samples and Quotes from Competitors

Request samples and quotes from: 
GFS Chemicals, Merck, Sachem (click on link)

Other Phase-Transfer Catalysts:
PTC Supplier Directory:
choose from a dozen suppliers & 80 PT catalysts and ask for free samples & quotes.

Inexpensive patent attorney (United States) familiar with Phase-Transfer Catalysis, organic chemistry and biochemistry. Contact Mannie Morgenstern by E-mail or at telephone 818-788-5531 (California). 

Free Subscription to Chemical Pilot Magazine - Chemical Pilot Magazine is a highly focused tool to help you understand the factors that drive success in the critical stage between idea creation and commercialization in the chemical industry. Each quarterly issue has five sections: emerging technologies, protecting your technology, staying competitive, education, government and policy. Register for your free subscription or send ideas for articles to


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Before performing any PTC reactions read this important message
Organic chemical reactions are inherently dangerous. Moreover, phase-transfer catalysis may provide rate and other enhancements which can intensify associated hazards. Under no circumstances should anyone perform any procedure on any scale based in whole or in part on any of the contents of this information provided here before thoroughly establishing safe operating procedures and performing a full and competent hazardous operations analysis with the participation of qualified technical personal trained in chemical, engineering, safety, industrial hygiene and environmental disciplines and sciences.

The list of PTC Tip of the Month subscribers will not be sold, rented or transferred and will be used only by PTC Communications, Inc. and PTC Organics, Inc. to provide information related to Phase-Transfer Catalysis. PTC Communications, Inc. reserves the right to distribute the PTC Tip of the Month to selected industrial chemists, engineers and managers.

PTC Tip of the Month #24 -September 2004
Copyright 2004 PTC Communications, Inc.

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