Chemical Market Reporter published a full page article on Phase-Transfer Catalysis in the March 15 issue (Fine Chemicals Focus Report page FR8) skillfully written by Clay Boswell. If you are a subscriber with a password, you can read it on the CMR website. This is a good independent article to convince corporate executives who read CMR that PTC programs should be initiated to achieve cost savings to cope with today's competitive market.
PTC Tip
of the Month - High-Performance
PTC Technology for Licensing
PTC Organics has developed several proprietary high-performance phase-transfer
catalysis applications which may help your company achieve cost savings and
overall better process performance. These PTC systems are available for
licensing. If any of these applications may be useful in your current
manufacturing or new process development, please contact Marc Halpern at +1
856-222-1146 or by E-mail.
Please
forward this PTC Tip of the Month to your colleagues and encourage them
to
subscribe
PTC
Training - 2-day PTC Course
The 2-day course "Practical
Phase-Transfer Catalysis" will be conducted in the US in May 2004.
Click here
for agenda. Click here
for registration or contact us by E-mail,
website, telephone (+1
856-222-1146) or fax (+1 856-222-1124).
May 3-4, 2004 - Mt. Laurel, New
Jersey (near PTC Organics)
Anytime - private
in-house course (optional Opportunity Identification Session under secrecy
agreement)
PTC
Training - 1-hr PTC Teleseminar
on June 1, 2004- FREE
PTC Organics is offering to selected
qualified companies a private session of the PTC tele-seminar entitled "Reducing Cost of Manufacture of Organic
Chemicals Using Phase-Transfer Catalysis" see abstract at www.ptcorganics.comsemabs.htm.
If your company qualifies, the seminar will be conducted by telephone on
Tuesday, June 1, 2004 with a
PowerPoint presentation (to be sent prior to the seminar) and can be accessed from anywhere in the
world with a telephone. Register by contacting
Marc Halpern at tel 856-222-1146 (US) or by E-mail.
PTC
Organics reserves the right to determine the participating companies which will
be selected from the industrial customers or potential industrial customers of
PTC Organics.
Inexpensive patent attorney (United States) familiar with Phase-Transfer Catalysis, organic chemistry and biochemistry. Contact Mannie Morgenstern by E-mail or at telephone 818-788-5531 (California).
Need
a 10% Yield Increase?
Process Improvement?
Contact PTC Organics by E-mail,
website, telephone (+1
856-222-1146) or fax (+1 856-222-1124) to
achieve rapid BREAKTHROUGH process
improvement and improve profit margin and competitiveness using Phase-Transfer
Catalysis for:
* Etherification * N-Alkylation * C-Alkylation *
S-Alkylation * Cyanation * Dehydrohalogenation * Reactions of HCl/HBr * Strong
Base Reactions using NaOH instead of methoxide, t-butoxide, sodium amide, sodium
hydride, sodium metal * Michael Addition * Aldol Condensation * Wittig * Carbene
Reactions * Darzens Condensation *
* Esterification * Transesterification * Nucleophilic Substitution using
Fluoride, Iodide, Bromide, Azide, Hydroxide, Cyanide, Alkyl Halides,
Epichlorohydrin, Allyl Chloride, Benzyl Chloride, Acyl Halides, Sulfonyl
Halides, Methane Sulfonyl Chloride, Phosphoryl Halides, Carbamoyl Halides,
Anhydrides, Thiocyanate, Sulfite, Nitrite *
* Oxidation using Hypochlorite, Hydrogen Peroxide, Oxygen, Permanganate,
Dichromate * Epoxidation * Reduction * Borohydride * Hydrogenation *
As the world leader in industrial
phase-transfer catalysis, PTC Organics offers PTC
Breakthrough Process Screening for rapid and highly effective evaluation of
breakthrough high-performance low-cost phase-transfer catalysis processes.
Pharma
-
for PTC options during route selection, contact Marc Halpern by E-mail,
website or telephone (+1
856-222-1146).
PT
Catalyst of the Month - Cetyl
Trimethyl Ammonium Bromide
Advantages
Inexpensive. Works well when interfacial tension needs to be reduced. Can be
introduced as an aqueous solution.
Disadvantages
Forms emulsions which may be very difficult to break which can make workup a
nightmare.
Reactivity
Parameters (Contact
PTC Organics for explanation)
Organophilicity
C# = 19; Accessibility q-value = 3.06 (forms tight ion pairs)
Availability, Samples and Quotes from Competitors
Request samples and quotes from: Zeeland,
Trigon
(click on link)
Other
Phase-Transfer Catalysts:
PTC
Supplier Directory: choose
from a dozen suppliers & 80 PT catalysts and ask for free samples &
quotes.
TDA-1 [Trisdioxaheptylamine
(70384-51-9)]: Joel Udell
published the availability of 200 kg of TDA-1 at $43/kg on 2/20/04. I haven't
seen this price since the early 1990's. Contact Joel directly at sandrine@earthlink.net
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and note "Subscribe to Tip" in the Comments or by telephone at +1
856-222-1146.
Before
performing any PTC reactions read this important message
Organic chemical reactions are inherently dangerous. Moreover, phase-transfer
catalysis may provide rate and other enhancements which can intensify associated
hazards. Under no circumstances should anyone perform any procedure on any scale
based in whole or in part on any of the contents of this information provided
here before
thoroughly establishing safe operating procedures and performing a full and
competent hazardous operations analysis with the participation of qualified
technical personal trained in chemical, engineering, safety, industrial hygiene
and environmental disciplines and sciences.
Policy
The list of PTC Tip of the Month subscribers
will not be sold, rented or transferred and will be used only by PTC
Communications, Inc. and PTC Organics, Inc. to provide information related to
Phase-Transfer Catalysis. PTC Communications, Inc. reserves the right to
distribute the PTC Tip of the Month to selected industrial chemists, engineers and
managers.
PTC Tip of the Month #19 - April 2004
Copyright 2004 PTC Communications, Inc.
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