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PTC Tip of the Month
Tetraoctyl Ammonium Bromide

At long last, tetraoctyl ammonium bromide is commercially available in drum quantities from several suppliers shown on the PTC Supplier Directory (PTC Organics does not sell phase-transfer catalysts). When do PTC experts use "TOAB"? Mostly for PTC "I-Reactions" in which we want to achieve high distribution into the organic phase and low accessibility of the positive charge on the nitrogen for loose ion pairing => high nucleophilicity of transferred anions. TOAB has both a high C# of 32 carbons for high organophilicity and a very low q-value of only 0.5 for loose ion pairing. In the past, we have had several PTC I-Reaction applications in which TOAB gave excellent reactivity, but until recently, we had to compromise on either C# or q-value for the commercial PTC breakthrough process. So we are glad to now be able to develop and scale up PTC processes using TOAB. For samples, please contact the suppliers DIRECTLY.

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PTC Seminar via Telephone & PowerPoint October 1, 2003 

PTC Organics will conduct the PTC seminar entitled "Reducing Cost of Manufacture of Organic Chemicals Using Phase-Transfer Catalysis" on October 1, 2003 at 09:00 US eastern standard time. The seminar will be conducted by telephone with a PowerPoint presentation on the web and can be accessed from anywhere in the world. Register by contacting Marc Halpern at tel 856-222-1146 (US) or by E-mail to receive your password, telephone number to call and other instructions.

Registration is free before September 1, 2003 and is limited to one access point per site (it is recommended that you use a speakerphone and projector connected to your computer for multiple participants). A total of 20 access points will be available. Preference will be given to multi-participant access points. PTC Organics reserves the right to determine the participating companies which will be selected from the industrial customers or potential industrial customers of PTC Organics.

PTC Reaction of the Month Creative Purification of a Raw Material Using PTC

An Eastman patent describes the use of PTC cyanation and bromination to separate an impure aliphatic bromide feedstock into useful compounds. The mixture (at left below) is prepared by the reaction of HBr with cyclopropyl methanol and separation of components is difficult. The inventor reacted the mixture with NaCN in the presence of Aliquat® 336. All of the cyclopropyl methyl bromide and bromobutene were consumed vs. only 1% of the cyclobutyl bromide. Then the reaction mixture was treated with bromine, which reacted only with the bromobutene. The final reaction mixture was easily separated by distillation, isolating two high value added products, cyclopropyl acetonitrile and cyclobutyl bromide. Hyatt, J., (Eastman Chemical) 2001 US Patent 6,191,300.


PTC Breakthrough Process Screening

PTC Organics offers PTC Breakthrough Process Screening for rapid and highly effective evaluation of breakthrough phase-transfer catalysis processes. As the world leader in industrial phase-transfer catalysis, PTC Organics develops breakthrough high-performance low-cost PTC processes. Contact Marc Halpern at PTC Organics by E-mail, website, telephone (+1 856-222-1146) or fax (+1 856-222-1124).

Have a Great Idea and Low Budget?

Great ideas make great chemists and engineers. If you have a really good opportunity related to PTC but low budget for screening & development, PTC Organics may be willing to consider screening and developing the opportunity under a customized licensing agreement. Your idea will be judged upon estimated technical probability of success, marketing probability of success, commercial potential and company status. For more details and a secrecy agreement, contact Marc Halpern at PTC Organics by E-mail, website, telephone (+1 856-222-1146) or fax (+1 856-222-1124). Do not disclose proprietary information without a secrecy agreement.

Conferences - Meet PTC Organics 

Informex Corporate Excellence Conference - September 15-16, 2003 in Cambridge, Maryland, USA
CPhI - October 27-29, 2003 in Frankfurt, Germany 
Informex 2004 - January 19-22, 2004 in Las Vegas, Nevada, USA
PTC Organics is a member of SOCMA


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Before performing any PTC reactions read this important message
Organic chemical reactions are inherently dangerous. Moreover, phase-transfer catalysis may provide rate and other enhancements which can intensify associated hazards. Under no circumstances should anyone perform any procedure on any scale based in whole or in part on any of the contents of this E-mail before thoroughly establishing safe operating procedures and performing a full and competent hazardous operations analysis with the participation of qualified technical personal trained in chemical, engineering, safety, industrial hygiene and environmental disciplines and sciences.

The list of PTC Tip of the Month subscribers will not be sold, rented or transferred and will be used only by PTC Communications, Inc. and PTC Organics, Inc. to provide information related to Phase-Transfer Catalysis. PTC Communications, Inc. reserves the right to distribute the PTC Tip of the Month to selected industrial chemists, engineers and managers.

PTC Tip of the Month #10 - July 2003
Copyright 2003 PTC Communications, Inc.

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