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PTC Tip
of the Month - Tetraoctyl
Ammonium Bromide
At long last, tetraoctyl ammonium bromide is commercially available in drum
quantities from several suppliers shown on the PTC
Supplier Directory (PTC Organics does not sell phase-transfer catalysts).
When do PTC experts use "TOAB"? Mostly for PTC "I-Reactions" in which
we want to achieve high distribution into the organic phase and low
accessibility of the positive charge on the nitrogen for loose ion pairing =>
high nucleophilicity of transferred anions. TOAB has both a high C# of 32
carbons for high organophilicity and a very low q-value of only 0.5 for loose
ion pairing. In the past, we have had several PTC I-Reaction applications in
which TOAB gave excellent reactivity, but until recently, we had to compromise
on either C# or q-value for the commercial PTC breakthrough process. So we are
glad to now be able to develop and scale up PTC processes using TOAB. For
samples, please contact
the suppliers DIRECTLY.
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PTC
Seminar via Telephone & PowerPoint - October
1, 2003
PTC Organics will conduct the PTC seminar entitled "Reducing Cost of Manufacture of Organic
Chemicals Using Phase-Transfer Catalysis" on October 1, 2003 at 09:00 US
eastern standard time. The seminar will be conducted by telephone with a
PowerPoint presentation on the web and can be accessed from anywhere in the world. Register by contacting
Marc Halpern at tel 856-222-1146 (US) or by E-mail
to receive your password, telephone number to call and other instructions.
Registration
is free before September 1, 2003 and is limited to one access point per site (it
is recommended that you use a speakerphone and projector connected to your
computer for multiple participants). A total of 20 access points will be
available. Preference will be given to multi-participant access points. PTC
Organics reserves the right to determine the participating companies which will
be selected from the industrial customers or potential industrial customers of
PTC Organics.
PTC Reaction of the Month - Creative
Purification of a Raw Material Using PTC
An Eastman patent describes the use of PTC cyanation and bromination to separate
an impure aliphatic bromide feedstock into useful compounds. The mixture (at
left below) is prepared by the reaction of HBr with cyclopropyl methanol and
separation of components is difficult. The inventor reacted the mixture with
NaCN in the presence of Aliquat® 336. All of the cyclopropyl methyl bromide and
bromobutene were consumed vs. only 1% of the cyclobutyl bromide. Then the
reaction mixture was treated with bromine, which reacted only with the
bromobutene. The final reaction mixture was easily separated by distillation,
isolating two high value added products, cyclopropyl acetonitrile and cyclobutyl
bromide. Hyatt, J., (Eastman Chemical) 2001 US Patent 6,191,300.
PTC Breakthrough Process Screening
PTC Organics offers PTC
Breakthrough Process Screening for rapid and highly effective evaluation of breakthrough
phase-transfer catalysis processes. As the world leader in industrial
phase-transfer catalysis, PTC Organics develops
breakthrough high-performance low-cost PTC processes. Contact Marc
Halpern at PTC Organics by E-mail,
website, telephone (+1
856-222-1146) or fax (+1 856-222-1124).
Have a Great Idea and Low Budget?
Great ideas make great chemists and engineers. If you have a really good
opportunity related to PTC but low budget for screening & development, PTC
Organics may be willing to consider screening and developing the opportunity
under a customized licensing agreement. Your idea will be judged upon estimated
technical probability of success, marketing probability of success,
commercial potential and company status. For more details and a secrecy agreement,
contact Marc
Halpern at PTC Organics by E-mail,
website, telephone (+1
856-222-1146) or fax (+1 856-222-1124). Do not disclose proprietary information
without a secrecy agreement.
Conferences
- Meet PTC Organics
Informex
Corporate Excellence Conference - September 15-16, 2003 in Cambridge,
Maryland, USA
CPhI - October 27-29, 2003 in
Frankfurt, Germany
Informex 2004 - January
19-22, 2004 in Las Vegas, Nevada, USA
PTC Organics is a member of SOCMA
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Before
performing any PTC reactions read this important message
Organic chemical reactions are inherently dangerous. Moreover, phase-transfer
catalysis may provide rate and other enhancements which can intensify associated
hazards. Under no circumstances should anyone perform any procedure on any scale
based in whole or in part on any of the contents of this E-mail before
thoroughly establishing safe operating procedures and performing a full and
competent hazardous operations analysis with the participation of qualified
technical personal trained in chemical, engineering, safety, industrial hygiene
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PTC Tip of the Month #10 - July 2003
Copyright 2003 PTC Communications, Inc.
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