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Tip of the Month
Recover Chiral Phase-Transfer Catalyst

A particularly useful tip was reported by Lygo et al (Lygo, B.; Crosby, J.; Lowdon, T.; Peterson, J.; Wainwright, P. Tetrahedron, 2001, 57, 2403). The highly effective anthracenylmethyl cinchona PTC quat could be easily recovered from the reaction matrix (toluene as the solvent) by filtering through a short column of MgSO4, then washing the MgSO4 with chloroform.
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PTC Reaction of the Month - Chiral Alkylation

As reviewed in the new Issue 17 of "Industrial Phase-Transfer Catalysis," Maruoka's group innovated a highly effective and stable chiral phase-transfer catalyst which routinely provides high ee and high yield using only 1 mole% of the catalyst. The catalyst structure is shown in Figure 8 on page 12 of Issue 17. The reaction below was reported with 97% ee and 90% isolated yield. Ooi, T.; Takeuchi, M.; Ohara, D.; Maruoka, K. Synlett, 2001, 7, 1185

PTC 2-Day Course - May 2003 in New Jersey

May 6-7, 2003 in New Jersey or train your whole department on-site, in-house. A veteran pharmaceutical process chemist wrote (Apr 2002 course): "Best training in my 18 years in industry." 

The PTC Technology & Information Center NEW  

Download back issues or individual articles from "Industrial Phase-Transfer Catalysis," "The "PTC Tip of the Month," "PTC Forum & Message Board" (active since 1996) and much more.

PTC Process Screening NEW 

PTC Organics now offers PTC Process Screening for rapid and highly effective evaluation of breakthrough phase-transfer catalysis processes. As the world leader in industrial phase-transfer catalysis, PTC Organics develops high-performance low-cost PTC processes. Contact Marc Halpern at PTC Organics by E-mail, website, telephone (+1 856-222-1146) or fax (+1 856-222-1124). Not sure if PTC can help improve performance? Just call and let's talk about PTC. Click here for 41 high-performance PTC reaction categories and benefits
(allow 60 sec for downloading pdf file).

Issue 17 of "Industrial PTC" Just Published

Download Issue 17 (316K pdf file)

The PTC Supplier Directory Coming in January 2003

Request samples and competitive quotes directly from the commercial suppliers of quats, PEG's, crowns, chiral PTC's, hi-temp PTC's and ionic liquids. QUIZ: Which of the following are suppliers of TBAB? Acme-Sujan, Cognis, Delta Finochem, Dishman, GFS, Lion Akzo, Nehachem, Sachem, Zeeland. ANSWER: ALL. Coming in Jan 2003: search > 80 PTC's. Are you a PTC manufacturer and want to be listed? Click here.

Informex 2003

Contact PTC Organics or call Marc Halpern at +1 856-222-1146 to arrange a meeting at Informex 2003 booth 1611. If you arrange the meeting before January 7, we will reserve for you a complimentary copy of the CD "The Best of Industrial Phase-Transfer Catalysis."


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PTC Tip of the Month #3
Copyright 2002 PTC Communications, Inc.