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Tip
of the Month - Save
Borohydride Cost Using PTC
Want to save money by using less borohydride? It turns out that PTC-borohydride
reductions use less borohydride than classical ethanolic borohydride because
borohydride is more stable in water than in ethanol. For example, a 98% yield of
Terfenadine was achieved using only 4 mole% excess NaBH4 with PTC
instead of 30 mole% excess using ethanolic NaBH4 without PTC (Magni,
A. [Gruppo Lepetit] 1989 Eur. Pat. EP 0 346 765). Learn more about
PTC borohydride reduction at the 2-Day
Practical PTC course in New Jersey in May 2003. TIP:
You can quickly screen your PTC-borohydride idea by using the newly available
tetrabutyl ammonium borohydride salt available from GFS. Contact information can
be found on the Phase-Transfer
Catalyst Supplier Directory launched last month.
Please
forward the PTC Tip of the Month to your industrial colleagues
PTC 2-Day Course - registration
deadline soon
Register
for the 2-day course "Practical Phase-Transfer Catalysis" to be held
in New Jersey on May 6-7, 2003 (click for agenda)
or train your whole department on-site, in-house.
A veteran pharmaceutical process chemist wrote (Apr 2002 course): "Best training in my 18
years in industry." He also reported scaling up a new PTC process in
November 2002. 87 companies have participated in 28 public and private in-house
courses in the US and Europe. Registration is now open. Registration Deadline:
April 1, 2003 (or March 1, if you need an invoice).
PTC Reaction of the Month -
Chiral Borohydride Reduction
& Collaboration Opportunity
Professor Tom Pochapsky at Brandeis was the first innovator of the chiral
anthracenylmethyl cinchona PTC quats (represented as Q*+ Cl-
in the figure). US Patent Application 20020115896
(Aug 2002) describes the chiral borohydride reduction shown below.
Pharmaceutical and agrochemical R&D scientists and managers are encouraged
to contact Professor Pochapsky to explore collaboration on chiral PTC through:
Sheryl M. Greenberg, Ph.D., Office of Intellectual Property & Technology
Transfer, Brandeis University MS115, 415 South Street, Waltham, MA
02454-9110, Tel: 781-736-2128, Fax: 781-736-2168, E-mail: sgreenberg@brandeis.edu.
- "Best
of Industrial PTC"
We appreciate your interest in PTC Organics'
services for screening, developing and commercializing high-performance low-cost
PTC processes. We will send you a gift of appreciation: the CD-ROM "The
Best of Industrial Phase-Transfer Catalysis" if you call Marc Halpern at +1 856-222-1146
or Contact PTC Organics
and write in the "Comments" section "please send me the CD-ROM
Best of Industrial PTC" by February 2003. The CD's will be sent in March
2003. Limit: one CD per person and you must provide a valid industrial address.
PTC Supplier Directory -
very useful resource
Very useful resource: Phase-Transfer
Catalyst Supplier Directory. Free and very easy
to use (2 clicks). One click to find multiple suppliers from around the world
for > 75 phase-transfer catalysts, including quaternary ammonium &
phosphonium quats, polyethylene glycols and their ethers, crown ethers, chiral
PTC's, ionic liquids and high-temperature phase-transfer catalysts. The second
click gives you full supplier contact information, website and E-mail useful
for requesting samples and requesting competitive quotes directly from multiple
suppliers.
Informex
2003 -
PTC Organics Exhibitor Showcase
Contact PTC Organics
or call Marc Halpern at +1 856-222-1146 to arrange a meeting at Informex 2003
booth 1611 to discuss how we can help you screen, develop and commercialize
high-performance low-cost PTC processes. PTC Organics will present at the
Exhibitor Showcase at 2:20 pm on Tuesday, February 25.
PTC
Process Screening
PTC Organics now offers PTC Process Screening for rapid and highly effective evaluation of breakthrough
phase-transfer catalysis processes. As the world leader in industrial
phase-transfer catalysis, PTC Organics develops
high-performance low-cost PTC processes. Contact Marc
Halpern at PTC Organics by E-mail,
website, telephone (+1
856-222-1146) or fax (+1 856-222-1124). Not sure if PTC can help improve
performance? Just call and let's talk about PTC. Click
here for 41 high-performance PTC reaction
categories and benefits (allow 60 sec for downloading pdf
file).
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PTC Tip of the Month #5
Copyright 2003 PTC Communications, Inc.