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Tip of the Month
Save Borohydride Cost Using PTC

Want to save money by using less borohydride? It turns out that PTC-borohydride reductions use less borohydride than classical ethanolic borohydride because borohydride is more stable in water than in ethanol. For example, a 98% yield of Terfenadine was achieved using only 4 mole% excess NaBH4 with PTC instead of 30 mole% excess using ethanolic NaBH4 without PTC (Magni, A. [Gruppo Lepetit] 1989 Eur. Pat. EP 0 346 765). Learn more about PTC borohydride reduction at the 2-Day Practical PTC course in New Jersey in May 2003. TIP: You can quickly screen your PTC-borohydride idea by using the newly available tetrabutyl ammonium borohydride salt available from GFS. Contact information can be found on the Phase-Transfer Catalyst Supplier Directory launched last month.

Please forward the PTC Tip of the Month to your industrial colleagues

PTC 2-Day Course - registration deadline soon

Register for the 2-day course "Practical Phase-Transfer Catalysis" to be held in New Jersey on May 6-7, 2003 (click for agenda) or train your whole department on-site, in-house. A veteran pharmaceutical process chemist wrote (Apr 2002 course): "Best training in my 18 years in industry." He also reported scaling up a new PTC process in November 2002. 87 companies have participated in 28 public and private in-house courses in the US and Europe. Registration is now open. Registration Deadline: April 1, 2003 (or March 1, if you need an invoice).

PTC Reaction of the Month - Chiral Borohydride Reduction & Collaboration Opportunity

Professor Tom Pochapsky at Brandeis was the first innovator of the chiral anthracenylmethyl cinchona PTC quats (represented as Q*+ Cl- in the figure). US Patent Application 20020115896 (Aug 2002) describes the chiral borohydride reduction shown below. Pharmaceutical and agrochemical R&D scientists and managers are encouraged to contact Professor Pochapsky to explore collaboration on chiral PTC through: Sheryl M. Greenberg, Ph.D., Office of Intellectual Property & Technology Transfer, Brandeis University MS115, 415 South Street, Waltham, MA  02454-9110, Tel: 781-736-2128, Fax: 781-736-2168, E-mail:


Gift of Appreciation - "Best of Industrial PTC"

We appreciate your interest in PTC Organics' services for screening, developing and commercializing high-performance low-cost PTC processes. We will send you a gift of appreciation: the CD-ROM "The Best of Industrial Phase-Transfer Catalysis" if you call Marc Halpern at +1 856-222-1146 or Contact PTC Organics and write in the "Comments" section "please send me the CD-ROM Best of Industrial PTC" by February 2003. The CD's will be sent in March 2003. Limit: one CD per person and you must provide a valid industrial address.

PTC Supplier Directory - very useful resource

Very useful resource: Phase-Transfer Catalyst Supplier Directory. Free and very easy to use (2 clicks). One click to find multiple suppliers from around the world for > 75 phase-transfer catalysts, including quaternary ammonium & phosphonium quats, polyethylene glycols and their ethers, crown ethers, chiral PTC's, ionic liquids and high-temperature phase-transfer catalysts. The second click gives you full supplier contact information, website and E-mail useful for requesting samples and requesting competitive quotes directly from multiple suppliers.

Informex 2003 - PTC Organics Exhibitor Showcase

Contact PTC Organics or call Marc Halpern at +1 856-222-1146 to arrange a meeting at Informex 2003 booth 1611 to discuss how we can help you screen, develop and commercialize high-performance low-cost PTC processes. PTC Organics will present at the Exhibitor Showcase at 2:20 pm on Tuesday, February 25.

PTC Process Screening

PTC Organics now offers PTC Process Screening for rapid and highly effective evaluation of breakthrough phase-transfer catalysis processes. As the world leader in industrial phase-transfer catalysis, PTC Organics develops high-performance low-cost PTC processes. Contact Marc Halpern at PTC Organics by E-mail, website, telephone (+1 856-222-1146) or fax (+1 856-222-1124). Not sure if PTC can help improve performance? Just call and let's talk about PTC. Click here for 41 high-performance PTC reaction categories and benefits
(allow 60 sec for downloading pdf file).

The PTC Technology & Information Center  

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PTC Tip of the Month #5
Copyright 2003 PTC Communications, Inc.