Practical
Phase-Transfer Catalysis
The Industrial
Phase-Transfer
Catalysis Experts

"Practical Phase-Transfer Catalysis"

Course Content:

  • Introduction
  • Mechanism and Kinetics
  • Choosing Catalyst
    1. Quat Structure-Activity
    2. Catalyst Stability
    3. Catalyst Separation
    4. Available Catalysts

      5. (reactivity, separability, cost/wt factor, stability, toxicity, etc.)
  • Anion - Effects and Choice
  • Hydration - Role and Control
  • Choosing Solvent
    1. Solvent-Free PTC
  • Agitation
  • Guidelines-Evaluation & Optimization
    1. pKa Guidelines
    2. Integrated Guideline

      3. Reactivity, Separation & Stability
    3. Resource-Efficient PTC R&D
  • Patentable PTC Technology
  • Applications
  • Identifying PTC Opportunities
  • C-Alkylation
    1. Chiral Alkylation
  • O-Alkylation (Etherification)
  • S-Alkylation
  • N-Alkylation
  • Michael Addition
  • Aldol Condensation
  • Wittig
  • Darzens Condensation
  • Dehydrohalogenation
  • Carbene Reactions
  • Esterification
  • Thiophosphorylation
  • Cyanide
  • Azide
  • Fluoride
  • Other Nucleophilic Aliphatic & Aromatic Substitutions
  • Oxidation
  • Epoxidation
  • Reduction
  • HCl/HBr Reactions
  • Exercises
    1. optimizing catalyst
    2. replacing solvent
    3. choosing base
    4. optimizing hydration
    5. agitation
    6. identifying opportunities

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© 2002 PTC Communications, Inc.