The Industrial Phase-Transfer Catalysis Website

PTC Technology & Information Center | Contact Us

PTC Supplier Directory | PTC Courses | Industrial PTC LibrarySubscribe/Unsubscribe

Breakthrough PTC Process Screening

Breakthrough PTC Process Screening & Development Program

Goal - Rapid Expert Screening of Breakthrough High-Performance PTC Process

PTC Organics applies highly-specialized expertise in Phase-Transfer Catalysis to innovate and evaluate proof-of-concept for breakthrough high-performance low-cost PTC processes. Innovation, performance and time are of the essence. PTC Organics determines proof-of-concept typically within 1 month of laboratory evaluation by PTC Organics’ dedicated PTC experts. PTC Organics typically delivers all three of "the big three":

[1] high performance breakthrough evaluation
[2] fast
[3] cost effective

Once proof-of-concept is established, the customer can [1] take the process in-house for further development or [2] contract with PTC Organics to perform "PTC Development" to achieve a high-performance PTC process ready for scale-up.

When to Consider Breakthrough PTC Process Screening

  • Route selection
  • Early stage process development
  • Major process improvement, cost reduction program (e.g., Six Sigma) or other strong driving force for breakthrough performance for cases in which the PTC Cost Savings Program (licensing) is not available

Initiating the Project

A project is initiated when the customer provides a "Project Description" under secrecy agreement (click for sample form and hypothetical example). The Project Description is a rather simple form which includes drawings of the specific molecular structures of the product and reactants for a specific chemical reaction and a summary of the desired Performance Targets for the reaction. The customer optionally (preferably) attaches background information about the reaction and process constraints for the project. It is usually the case that the integration of PTC Organics’ expertise with the background project expertise of the customer’s chemists and engineers leads to the most efficient use of development resources while enhancing the probability of success. Such an initial discussion is highly recommended prior to starting the laboratory program.

Breakthrough PTC Process Screening in PTC Organics’ Laboratory

PTC Organics dedicates its best efforts, highly specialized expertise in Phase-Transfer Catalysis and laboratory resources to design, redesign and execute an experimental program in PTC Organics’ laboratory, including highly specialized PTC techniques, to determine proof-of-concept and promising results for the PTC process option. In order to determine proof-of-concept, Breakthrough PTC Process Screening typically focuses on the 3 to 5 parameters which are most likely to be responsible for most of the behavior of the PTC system (out of a possible 14 factors) while applying highly specialized PTC techniques for these factors and defining the ranges for the parameters in which high performance is most likely to be achieved.

PTC Screening Report

At the end of Breakthrough PTC Process Screening, PTC Organics composes a PTC Screening Report. The report describes the procedures, results and rationale for the design of the experimental program. The report provides analysis of the results and ramifications as measured against the pre-defined Performance Targets. The report also includes a critique of selected relevant PTC literature. Overall, the PTC Screening Report provides an excellent basis for making decisions justified by data, rationale and the best PTC expertise available with cost-effective investment of resources.

Terms of Breakthrough PTC Process Screening

Breakthrough PTC Process Screening is provided at a flat fee which includes experimental programs designed and executed in PTC Organics’ laboratory and the PTC Screening Report. More specifically, the flat fee includes all internal expertise of PTC Organics’ experts, all lab work, written reports, one initial and one final meeting at PTC Organics’ site, waste disposal, supplies, analytical (GC, HPLC, Karl Fischer and other wet methods are included; does not include GC-MS, LC-MS or NMR) and all other routine lab activities. Chemicals which cost $20 per kg or less including commercially available phase-transfer catalysts, routine solvents and routine chemicals are included. Raw materials, analytical samples, analytical methods and MSDS’s are provided by the customer. Certain chemistries are not performed by PTC Organics, such as work with controlled substances, high potency materials (LD50 oral-rat < 1 mg/kg) phosgene and lower mercaptans. Most other chemistries are acceptable, including work with cyanide, azide, epichlorohydrin, dimethyl sulfate, acrylonitrile, benzyl chloride, allyl chloride, PCl3, fluoride and most standard organic and inorganic chemicals. Special capital items, travel to the customer site, additional face-to-face meetings and other non-routine items are not included. In practice, it is rare that any additional fees are incurred beyond the flat fee.

Optional - PTC Development in PTC Organics’ Laboratory

If proof-of-concept is achieved during Breakthrough PTC Process Screening, the customer can request PTC Development by PTC Organics which is focused on developing a high-performance PTC process ready for scale-up. The duration of the project and process parameters evaluated are specific to each process and generally include: identity of the phase-transfer catalyst, solvent, hydration factors, identity of base (this is often the key parameter when relevant), effects of anion & leaving group, co-catalyst, agitation, concentrations & mole ratios, temperature and order & rate of addition. The results monitored are specific to each process and generally include: conversion rate (kinetic profile), selectivity (especially for water-sensitive reactants & products) and isolated yield & product assay (if the customer chooses to invest in developing separation/work-up procedures). A detailed Development Report is issued at the end of PTC Development. Scale-up should not be performed before conducting a formal comprehensive safety and environmental review (hazop analysis, etc.).

Contact Dr. Marc Halpern at PTC Organics

tel: +1 856-222-1146      fax: +1 856-222-1124      E-mail

go to top

PTC Supplier Directory | PTC Courses | Industrial PTC Library | Subscribe/Unsubscribe

Contact Us | Home

© 2004 PTC Communications, Inc.